BindingDB BDBM7266 14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,17}]octadeca-1(11),2,4,6,12(17),13,15-heptaen-9-one::9-bromopaullone::CHEMBL296586::Kenpaullone::NSC 664704::Paullone Analog 5::cid

BDBM7266 14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,17}]octadeca-1(11),2,4,6,12(17),13,15-heptaen-9-one::9-bromopaullone::CHEMBL296586::Kenpaullone::NSC 664704::Paullone Analog 5::cid_3820

SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1

InChI Key InChIKey=QQUXFYAWXPMDOE-UHFFFAOYSA-N

Data 3 KI 63 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 7266

Cyclin-dependent kinase 2(Homo sapiens (Human))
University of Dundee

Curated by PDSP K_i Database

BDBM7266(14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...)

Ki: 670nMMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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B.MOAD DrugBank antibodypedia GoogleScholar

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Filter my 66 hits

Targets 32▿
- Glycogen synthase kinase-3 beta 9
- Platelet-derived growth factor receptor alpha/beta 8
- Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B1/G2/mitotic-specific cyclin-B2/G2/mitotic-specific cyclin-B3 4
- Mitogen-activated protein kinase 1 3
- Mitogen-activated protein kinase 3 3
- Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 3
- Cyclin-dependent kinase 5 activator 1 3
- Cyclin-dependent kinase 5 activator 1 [99-307] 2
- Tyrosine-protein kinase Lck 2
- Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B 2
- Dual specificity protein kinase CLK1 2
- Dual specificity tyrosine-phosphorylation-regulated kinase 1A 2
- Proto-oncogene tyrosine-protein kinase Src 2
- MO15-related protein kinase Pfmrk 2
- Insulin receptor 2
- Serine/threonine-protein kinase PLK1 1
- Ninein 1
- Steroidogenic factor 1 1
- Tyrosine-protein kinase ABL1 1
- Replicase polyprotein 1ab 1
- Casein kinase I isoform alpha 1
- Glycogen synthase kinase 3 1
- Casein kinase II subunit alpha 3 1
- RAF proto-oncogene serine/threonine-protein kinase 1
- Nuclear receptor subfamily 0 group B member 1 1
- Cyclin-dependent kinase 2 1
- Cyclin-A2/Cyclin-dependent kinase 2 1
- Cyclin-dependent kinase 1 1
- Cyclin-T1/Cyclin-dependent kinase 9 1
- NAD-dependent protein deacetylase sirtuin-2 1
- Vascular endothelial growth factor receptor 2 1
- Casein kinase II subunit alpha 1
- ...
Publications 23▿
- Bioorg Med Chem Lett 20: 4940-4 (2010) 8
- Proc Natl Acad Sci U S A 104: 20523-8 (2007) 6
- Eur J Biochem 267: 5983-94 (2000) 3
- Biochem J 371: 199-204 (2003) 3
- Bioorg Med Chem Lett 14: 413-6 (2004) 3
- J Med Chem 53: 2433-42 (2010) 3
- Eur J Med Chem 45: 335-42 (2010) 2
- J Med Chem 46: 876-9 (2003) 2
- Trends Pharmacol Sci 25: 471-80 (2004) 2
- J Med Chem 47: 5418-26 (2004) 1
- Bioorg Med Chem Lett 10: 567-9 (2000) 1
- J Med Chem 49: 7307-16 (2006) 1
- J Med Chem 65: 955-982 (2022) 1
- Eur J Med Chem 210: (2021) 1
- J Med Chem 42: 2909-19 (1999) 1
- PubChem Bioassay (2013) 1
- Eur J Med Chem 45: 4316-30 (2010) 1
- J Med Chem 46: 3877-82 (2003) 1
- Eur J Med Chem 142: 244-265 (2017) 1
- J Med Chem 60: 8482-8514 (2017) 1
- PubChem Bioassay (2013) 1
- J Med Chem 51: 2196-207 (2008) 1
- Bioorg Med Chem Lett 24: 1532-7 (2014) 1
Institutions 19▿
- Trinity College 8
- Technische Universitat Braunschweig 6
- University Of Oxford 6
- Technische Universit£T Braunschweig 3
- University of Dundee 3
- Cnrs 3
- UniversitäT Hamburg 2
- Martin-Luther-University Halle-Wittenberg 2
- The Rockefeller University 2
- The Scripps Research Institute Molecular Screening Center 2
- Walter Reed Army Institute Of Research 1
- Novartis Institutes For Biomedical Research 1
- China Pharmaceutical University 1
- Northwestern University 1
- Babasaheb Bhimrao Ambedkar University 1
- University Of Jordan 1
- Institute Of Research 1
- Albert-Ludwigs-University Of Freiburg 1
- Eberhard Karls University T£Bingen 1
Affinity: 9 to 1.0E+6 nM▿
- Ki 3
- IC50 63
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1